Vance Henrik is a is a dangerous, hot-headed brute of a prisoner. Prone to violence and escape attempts, the prison system finally has enough, and decides to use an experimental drug to pacify him. Defiant, Vance tries to hold out as his body becomes increasingly feminine, and increasingly full of strange urges.

Two women wake up in a sterile, locked cell with no memory of how they got there. Trapped and terrified, they search for answers—only to find their bodies are beginning to change in ways they can’t control.